TheTimesTribune.com, Corbin, KY

Features

June 25, 2012

Tri-Countians sought for research study

CORBIN — By Carl Keith Greene / Staff Writer

Area residents have the chance to participate in a cancer study.

The American Cancer Society is beginning a research program called Cancer Prevention Study-3 (CPS-3).

On Tuesday, Aug. 7, Saint Joseph-London hospital will host persons between 30 and 65 years old who have never been diagnosed with cancer (not including basal or squamous cell skin cancer) who are willing to make a long-term commitment to the study.

It involves completing periodic follow-up surveys at home.

Those who wish to participate in this study should contact the American Cancer Society (ACS) by calling 888-604-5888 or visiting cancer.org/cps3 online.

The Saint Joseph-London visits will be scheduled between 7:30 a.m. to 12:30 p.m. and 4 p.m. to 6:30 p.m. and will be in the private dining room in the hospital’s cafeteria.

At the appointment, those wishing to participate will be asked to read and sign an informed consent form, complete a survey packet that asks for information on lifestyle, behavioral and other factors related to health. It will also ask for height, weight, blood pressure, heart rate and waist circumference measured.

Also a small blood sample will be taken by a trained phlebotomist.

Four studies have already begun. Two have been completed, two more are still pending and being conducted and CPS-3 is in the process of beginning.

In 1952-1955 the Hammond-Horn Study included 188,000 U.S. men recruited by 22,000 volunteers as the first large effort to study the effect of cigarette smoking on death rates from cancer and other diseases.

Hammon-Horn set the methods of two subsequent Cancer Prevention Studies, CPS-I and CPS II.

CPS-I from 1959-1972 included about a million men and women recruited by 68,000 volunteers in 25 states. CPS-I looked into a wide range of potential exposures, in addition to tobacco use, that may incrase or decrease cancer risk.

Cancer Prevention Study, CPS-II began in 1982 and continues. About 1.2 million subjects in 50 states, Washington, DC, and Puerto Rico were recruited.

The participants have been followed over 20 years to determine causes of death. The study was to determine causes of death. It was, like CPS-I designed for a wide range of environmental and lifestyle exposures that could increase or decrease cancer risk.

In 1992, CPS-II Nutrition Cohort began in 21 states where about 185,000 were enrolled. It continues.

The study was designed to understand how diet affects the cancer risk.

Periodically questionnaires are sent to the members to update exposure information and follow them for cancer occurrence and all causes of death.

CPS-3 is intended to help researchers understand the lifestyle, environmental and genetic factors that cause or prevent cancer.

The principal investigator of CPS-3, Alpa V. Patel, Ph.D., said, “Many individuals diagnosed with cancer struggle to answer the question, ‘What caused my cancer?’ In many cases, we don’t know the answer.”

He added, “CPS-3 will help us better understand what factors cause cancer and once we know that, we can be better equipped to prevent cancer.”

Previous cancer prevention studies have helped in identifying some of the major factors of cancer risk.

CPS-3 holds the best hope of spotting new and emerging cancer risks. “We can only do this if members of the community are willing to become involved,” he said.

Diverse study subjects are needed to  enroll in the CPS-3 program since the research applies to a diverse population.

Researchers must be able to look into cancer and its impact on various racial-ethnic populations.

For Hispanics, liver cancer rates are higher than in whites. CPS-3 will provide a means to understand why.

Also, rates of obesity are increasing in U.S. Hispanic populations, as well as in most other populations, and it is known that obesity is related to various types of cancer. CPS-3 will allow the examination impact of those changes in population and its affect on cancer risk for future generations.

Historically, African American men have higher incidence of prostate cancer compared to white men. Reasons are unclear and CPS-3 will allow better understanding.

For more information from the American Cancer Society nationally call 1-800-1227-2345, or go to cancer.org <http://www.cancer.org>.

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